About the Role Our client is a pioneering company in the field of synthetic biology, developing novel solutions for industrial biotechnology and sustainable manufacturing. We are seeking a highly experienced Principal Scientist, Synthetic Biology to join our innovative team. This hybrid role is based in **Denver, Colorado, US**, offering a stimulating environment that combines essential lab work with remote flexibility for analysis and strategic planning. You will lead the design, construction, and optimization of novel biological systems and metabolic pathways for the production of high-value compounds. This position requires a deep understanding of molecular biology, metabolic engineering, genetic circuits, and high-throughput screening. You will manage complex projects, mentor junior scientists, and collaborate extensively with cross-functional teams, including bioengineering, process development, and computational biology. The ideal candidate possesses a proven track record of successful synthetic biology projects, strong leadership skills, and a passion for innovation in industrial biotechnology. This is an exceptional opportunity to drive impactful research and shape the future of sustainable manufacturing. Key Responsibilities Lead the design, construction, and testing of engineered biological systems and pathways. Develop and implement strategies for metabolic engineering and strain optimization. Apply principles of genetic circuit design and implementation for complex cellular functions. Oversee high-throughput screening and selection methods for identifying optimized strains or pathways. Collaborate with computational biologists to develop predictive models and guide experimental design. Mentor and guide junior scientists and research associates in synthetic biology techniques. Analyze complex experimental data, interpret results, and make data-driven decisions. Present research findings to internal teams, management, and external collaborators. Contribute to intellectual property development and scientific publications. Ensure adherence to laboratory safety standards and company procedures. Requirements Ph.D. in Synthetic Biology, Molecular Biology, Bioengineering, Chemical Engineering, or a related field. Minimum of 7 years of relevant research experience, with a significant focus on synthetic biology applications. Proven experience in metabolic engineering, genetic circuit design, and genome engineering. Hands-on expertise with molecular cloning, DNA assembly methods, and microbial genetics. Experience with high-throughput screening platforms and automation is highly desirable. Strong understanding of statistical analysis and experimental design. Demonstrated leadership experience and the ability to manage complex projects. Excellent problem-solving, analytical, and critical thinking skills. Superb written and verbal communication skills, with strong presentation abilities. Comfortable working in a hybrid model, balancing on-site lab work with remote analysis. Benefits Our client offers a highly competitive salary, performance-based bonuses, and a comprehensive benefits package, including health, dental, and vision insurance, a 401(k) plan with company match, and generous paid time off. We are committed to fostering a culture of innovation, collaboration, and scientific advancement. This hybrid position, located in **Denver, Colorado, US**, offers a stimulating research environment with ample opportunities for professional growth. Join our team and contribute to groundbreaking advancements in synthetic biology for a sustainable future.